Pfizer to vacate 164K sf

181 Oyster Point Blvd is listed as The Cove at Oyster Point’s Building 5 and the property listing shows a total rentable area of about 164,150 square feet for that address. (cushmanwakefield.com) Current marketing materials show four immediate sublease availabilities at 181 Oyster Point with full-floor suites of 33,771 SF, 36,884 SF, 36,838 SF and 36,151 SF, each offered as sublease opportunities. (cushmanwakefield.com) The Cushman & Wakefield brochure lists an asking rental rate of $30.00 per SF (NNN) for the third-floor offering in the building. (cushmanwakefield.com) The Cove campus is owned/managed by Healthpeak (HCP) and the developer portfolio describes the Oyster Point campus as roughly a 1.0 million‑square‑foot, multi‑building waterfront life‑science campus with on‑site hotel, retail and LEED‑certified buildings. (healthpeak.com) Pfizer previously fielded a sublease campaign for roughly 91,000 square feet across the Oyster Point address before this latest move, according to coverage of the earlier marketing push. (bisnow.com) Kilroy’s Oyster Point Phase 2 reported roughly 300,000 square feet of additional lease executions in 2025, and UCSF signed a nearly 280,000‑square‑foot full‑building lease at Kilroy’s campus that will deliver in Q4 2027—both large nearby openings that affect absorption dynamics for a 164K SF vacancy. (markets.financialcontent.com) Marketing packets and LoopNet/Cushman listings highlight convenient access to US‑101 plus shuttle links to BART, Caltrain and ferry service and name campus amenities (AC Hotel, retail, fitness and conference space) that are being promoted to lab and AI‑adjacent occupiers. (loopnet.com) Cushman & Wakefield is handling the sublease listings for 181 Oyster Point and the public-facing materials identify Marc Pope and Cushman as the broker contacts on the availabilities. (commercialsearch.com)