SF Business Leaders Prioritize AI and M&A

A recent KPMG survey indicates that business leaders in San Francisco are prioritizing AI, M&A, talent acquisition, and collaborative office spaces to drive growth in 2026. This focus aligns with other local initiatives, such as new grants for neighborhood businesses and innovation in AI and healthcare. The trends suggest a strategic approach to leveraging technology and capital for economic development.

- According to a February 2026 KPMG report, 50% of San Francisco business leaders are likely to pursue acquisitions in 2026, with a significant 77% of those planning to act in the first half of the year. This M&A focus is particularly strong in the technology and life sciences sectors. - The drive for AI talent is reshaping hiring priorities, with Machine Learning Engineers in San Francisco commanding the highest base salaries in the nation, ranging from $156,000 to $301,000. This demand is fueled by local AI labs like OpenAI and Anthropic, creating intense competition for specialized skills. - San Francisco's AI sector is attracting substantial investment, highlighted by recent nine- and ten-figure funding rounds. Spatial AI startup World Labs recently secured a $1 billion investment, and AI observability software developer Braintrust raised $80 million. - To support small businesses, San Francisco's Office of Economic and Workforce Development (OEWD) launched $6.3 million in new grants in February 2026. The initiatives include the Storefront Opportunity Grant, which provides between $50,000 and $100,000 to help entrepreneurs open new storefronts in neighborhoods with high vacancy rates. - Additional city-funded programs aimed at revitalizing commercial corridors include the Vandalism Relief Grant, offering up to $2,000 for storefront damage repairs, and the Fire Disaster Relief Grant, which provides up to $10,000 for businesses impacted by fires for which they were not at fault. - A majority of business leaders are committed to physical office spaces, with 75% surveyed in a recent KPMG study planning to increase their commercial real estate footprint over the next 12-18 months. This coincides with a push for more frequent in-person collaboration.

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