Amsterdam UMC posts Alzheimer’s postdoc role

Amsterdam UMC has posted a postdoctoral vacancy for a researcher to work on Alzheimer’s drug discovery, according to a listing on its careers site. The role is a fixed-term, 12-month position based at VUmc and carries a salary range of 3,598 euros to 5,669 euros for 36 hours a week. The posting says the researcher will develop biochemical assays tied to APOE4, a genetic risk factor linked to Alzheimer’s disease. A post on X by DemResCommunity also shared the opening and linked to the job page. ### Which Alzheimer’s mechanism is the project targeting? The Amsterdam UMC listing says the project is aimed at APOE4-driven disease mechanisms. APOE4 is described in the posting as the strongest genetic risk factor for Alzheimer’s disease, and the project centers on blocking APOE4 uptake and reducing its toxic effects in the brain. The vacancy says the postdoctoral researcher will build a biochemical assay to study the interaction between APOE4 and its receptor. The same assay would then be used in drug-screening approaches, including fragment screening and DNA-encoded library screening, according to the listing. ### What would the researcher actually do in the lab? The job description says the researcher would establish biochemical assays that model APOE-receptor interactions using recombinant proteins. The posting also says the role includes running fragment screening and DNA-encoded library screening to identify compounds that disrupt APOE-receptor binding. Candidate compounds would then be checked with orthogonal biophysical assays and moved into preclinical characterization and optimization, the listing says. Amsterdam UMC says the work sits inside a broader neurodegenerative drug-discovery program at its Candidate Center. ### Who is involved besides Amsterdam UMC? VU Amsterdam is named in the posting as a collaborator on the project. Amsterdam UMC says the researcher will work closely with the group of Professor Iwan de Esch at the AIMMS institute of VU Amsterdam, where the listing says medicinal chemistry and structure-based modeling expertise are available. Amsterdam UMC says the role is part of a multidisciplinary translational research team. The posting says the researcher would collaborate across biochemistry, medicinal chemistry and neurodegeneration research at Amsterdam UMC and VU Amsterdam. ### What does the contract look like? The careers page lists the role as a fixed-term appointment for 12 months at 36 hours per week. The salary range shown on the posting is 3,598 euros to 5,669 euros, and the location is listed as VUmc. Amsterdam UMC’s English-language vacancies site shows the position under the title “Postdoctoral Researcher in Alzheimer’s Drug Discovery.” The opening appeared on the organization’s vacancies platform on May 20. ### Was an application deadline posted? Amsterdam UMC’s job page says applicants can respond until June 2, 2026. That adds a deadline not included in the social-media post that circulated the opening earlier on Wednesday. The careers listing directs applicants to apply through Amsterdam UMC’s vacancies portal. The page identifies the next step as submitting an application before June 2 for the VUmc-based postdoctoral role being carried out with VU Amsterdam.