APCCC26 flags prostate liquid biomarkers

- APCCC26 sessions emphasized integrating ctDNA, NEMO methylation for NEPC detection, and circulating tumor cells with transcriptional profiling for dynamic phenotyping. - Presenters showed how combining ctDNA and CTC transcriptional data can detect neuroendocrine prostate cancer features and guide therapy choices in advanced cases. - Translating these assays to cytology samples requires coupling morphology with molecular triage and specimen stewardship. (x.com)