DrCycloPath: marked pleomorphism in HGSC

- DrCycloPath described classic high‑grade serous carcinoma cytology: marked nuclear pleomorphism, brisk mitoses, and frequent TP53 mutations on social media. - The post noted an estimated 15% BRCA‑linked subset of high‑grade serous cases that may be PARP‑sensitive, linking cytology features to therapeutic considerations. - The thread reinforced that extreme pleomorphism with high mitotic activity on cytology should prompt immediate concern for high‑grade serous carcinoma. (x.com)