mRNA/spike persistence flagged
Researchers and commentators point to studies reporting spike protein and vaccine mRNA/DNA persistence — the longest reported persistence exceeds 3.5 years in some labs and compartments, and separate reviews highlight MRI‑detected post‑COVID brain changes in frontal/temporal/limbic regions. Epidemiologist Nicolas Hulscher summarized seven studies linking vaccines to cognitive and neuropsychiatric signals and noted spike persistence in cerebral arteries up to 17 months. ( )
A multi-author case report led by Nicolas Hulscher presents longitudinal molecular and tissue assays from a single 55-year-old patient and reports reproducible detection of vaccine-derived mRNA, plasmid DNA fragments and spike antigen across independent laboratories and assay platforms. (zenodo.org) The same Zenodo upload lists co-authors and affiliations including the McCullough Foundation and INMODIA GmbH, identifies the report as a detailed single-case investigation, and does not appear in a peer‑reviewed journal on the record page. (zenodo.org) A separate pathology series led by Nakao Ota examined 19 hemorrhagic stroke cases from 2023–2024 and reported immunohistochemical detection of spike protein localized to the intima of cerebral arteries in a subset of vaccinated patients, with in‑situ hybridization confirming vaccine‑origin mRNA in selected samples. (ScienceDirect, Journal of Clinical Neuroscience article: ) That Japanese series reported spike‑positive vessels in 43.8% of vaccinated cases in the cohort, noted spike positivity occurred only in female patients (P = 0.015), found infiltrating CD4/CD8/CD68 cells but no nucleocapsid protein (arguing against active SARS‑CoV‑2 infection), and framed its data as observational rather than causal. (ScienceDirect, Journal of Clinical Neuroscience article: ) Systematic and multimodal imaging work has converged on specific networks rather than diffuse injury: a 2024 systematic review of advanced MRI techniques summarized perfusion, microstructural and functional abnormalities in post‑COVID cohorts, while a 2025 multimodal MRI study reported consistent basal ganglia–limbic system alterations in survivors. (Link Springer systematic review: ) (medRxiv/IMAG preprint: ) Other longitudinal imaging studies reported focal hypoperfusion and functional changes in frontal and temporal regions and linked MRI differences to cognitive symptom clusters one year after mild infection, underscoring heterogeneous findings across methods and cohorts. (Scientific Reports hypoperfusion study 2023: ) (Nature Communications 2025 MRI + proteomics one‑year study: )
