Bryan Johnson posts psilocybin data
Bryan Johnson published first-in-human results from a quantified psilocybin experiment showing sharp drops in sperm motility/count (e.g., a 51% motility drop after a second dose) and changes in free testosterone tied to SHBG—he frames these as trade-offs for potential neuroplasticity and anti-inflammatory benefits. The post puts biohacker-style human n=1 data back into the longevity conversation with concrete, measurable effects. (x.com)
Johnson’s team says the protocol delivered three high-dose psilocybin sessions spaced across three months while measuring 249 blood, tissue and functional biomarkers — a scale the Blueprint post calls “the most quantified psychedelic experiment” to date. (blueprint.bryanjohnson.com) Johnson reported the first session dose as 4.67 grams of dried Psilocybe cubensis, which his log equates to 24.98 mg of psilocybin — a per-dose level comparable to several contemporary clinical trials. (threadreaderapp.com) His thread and associated posts list hormone shifts after the second session: direct (free) testosterone fell ~24% at 3 days and ~23% at 20 days, SHBG rose ~37%, while serum total testosterone transiently increased ~30% at day 3 and remained ~11% above baseline afterward. (youtube.com) Semen parameters beyond simple motility were reported: total motile count fell roughly 52% and normal morphology dropped about 50% at the acute post-dose timepoints Johnson published, with some later partial recovery on different metrics. (youtube.com) Blueprint’s write-ups frame these physiological hits as trade-offs tied to putative mechanistic gains Johnson highlights — increased neuroplasticity, reduced systemic inflammation, and shifts in telomere- and gene-expression markers measured alongside the psilocybin dosing. (blueprint.bryanjohnson.com) Johnson has previously published baseline reproductive metrics for himself — a reported sperm concentration of 143 million per mL and total sperm count around 380 million — which he uses to contextualize how post-dose declines compare to his unusually high starting values. (blueprint.bryanjohnson.com) The sessions were run with clinical-style monitoring and public visibility: Johnson describes medically supervised sampling, continuous biometrics and a livestreamed, documented trip that included co‑ordination with clinicians and real‑time data capture. (chillumdispensary.com)
