NAD⁺ Supplements Boost Cellular Energy
Nestlé research shows NAD⁺ supplements boost cellular energy and gut microbiome as NAD⁺ levels naturally decline with age. Other recent nutrition studies include research on cashew byproduct value-add through shelf-life testing and a pistachio meta-analysis for cardiovascular health. The NAD⁺ findings suggest potential benefits for aging-related cellular decline.
- The Nestlé study, published in *Nature Metabolism*, was the first clinical trial to directly compare three different NAD+ precursors: nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and nicotinamide (Nam). - The study found that after 14 days, both NR and NMN supplements significantly increased the levels of NAD+ in the blood of healthy adults, while nicotinamide (Nam) did not show a sustained increase. - A significant finding was the interaction with the gut microbiome; the research indicated that gut bacteria metabolize NR and NMN into other compounds, including nicotinic acid, which then contributes to the overall increase in the body's NAD+ levels. - This interaction with gut microbes also led to an increase in beneficial metabolites, such as short-chain fatty acids (SCFAs), which are known to support gut health and reduce inflammation. - NAD+ levels in the human body naturally decline with age, with an estimated 50% reduction by the age of 40 and as much as an 80% decrease by the age of 60. - This age-related decline in NAD+ is linked to various health issues, including cognitive decline, cardiovascular problems, and muscle loss. - While research in animals has shown promise for extending lifespan and improving health, large-scale human studies are still needed to confirm significant anti-aging or cognitive benefits of NAD+ supplementation. - NAD+ precursor supplements like NR and NMN are generally considered safe for healthy adults at recommended doses, with potential mild side effects such as digestive discomfort or headaches.
